Food Protein-Induced Enterocolitis Syndrome (FPIES)

FPIES is a delayed allergic reaction to a food protein, involving the GI (gastrointestinal) tract. Typical symptoms include delayed onset of repetitive profuse vomiting, usually 2-3 hours or more after ingesting the food. This may be associated with diarrhea and acute dehydration, lethargy and appearing tired. In severe cases and young infants, emergency care may be needed.

Unlike a “classic” type of food allergy, there are no hives, rashes, swelling, or wheezing. Since it is not IgE-mediated, FPIES does not show up on allergy skin testing. Onset usually occurs in the first year of life, most often between 4-8 months. Most children outgrow this type of allergy by 3-4 years of age. Diagnosis, treatment, and ongoing management should be discussed with an allergist.

http://fpiesfoundation.org/wp-content/uploads/2014/09/patient-packet.pdf